2a6a

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Current revision (06:43, 25 January 2023) (edit) (undo)
 
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<StructureSection load='2a6a' size='340' side='right'caption='[[2a6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2a6a' size='340' side='right'caption='[[2a6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2a6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A6A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2a6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A6A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tm0874 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a6a OCA], [https://pdbe.org/2a6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a6a RCSB], [https://www.ebi.ac.uk/pdbsum/2a6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a6a ProSAT], [https://www.topsan.org/Proteins/JCSG/2a6a TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a6a OCA], [https://pdbe.org/2a6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a6a RCSB], [https://www.ebi.ac.uk/pdbsum/2a6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a6a ProSAT], [https://www.topsan.org/Proteins/JCSG/2a6a TOPSAN]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSAB_THEMA TSAB_THEMA] Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thema]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Structural genomic]]
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[[Category: Glycoprotein endopeptidase]]
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[[Category: Hydrolase]]
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[[Category: Jcsg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Tm0874]]
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Current revision

Crystal structure of Glycoprotein endopeptidase (tm0874) from THERMOTOGA MARITIMA at 2.50 A resolution

PDB ID 2a6a

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OCA

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