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2h2w
From Proteopedia
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<StructureSection load='2h2w' size='340' side='right'caption='[[2h2w]], [[Resolution|resolution]] 2.52Å' scene=''> | <StructureSection load='2h2w' size='340' side='right'caption='[[2h2w]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2h2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H2W FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h2w OCA], [https://pdbe.org/2h2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h2w RCSB], [https://www.ebi.ac.uk/pdbsum/2h2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h2w ProSAT], [https://www.topsan.org/Proteins/JCSG/2h2w TOPSAN]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h2w OCA], [https://pdbe.org/2h2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h2w RCSB], [https://www.ebi.ac.uk/pdbsum/2h2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h2w ProSAT], [https://www.topsan.org/Proteins/JCSG/2h2w TOPSAN]</span></td></tr> | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/METAA_THEMA METAA_THEMA] Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Has weak activity with succinyl-CoA as the acyl donor.<ref>PMID:16708165</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h2w ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h2w ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 43589]] | ||
| - | [[Category: Homoserine O-succinyltransferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Thermotoga maritima]] |
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Revision as of 06:46, 25 January 2023
Crystal structure of Homoserine O-succinyltransferase (EC 2.3.1.46) (Homoserine O-transsuccinylase) (HTS) (tm0881) from THERMOTOGA MARITIMA at 2.52 A resolution
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