4ol9

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==Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate==
==Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate==
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<StructureSection load='4ol9' size='340' side='right' caption='[[4ol9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='4ol9' size='340' side='right'caption='[[4ol9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ol9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OL9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ol9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OL9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2573, MT2649, MTCY227.28c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ol9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ol9 OCA], [https://pdbe.org/4ol9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ol9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ol9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ol9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydropantoate_2-reductase 2-dehydropantoate 2-reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.169 1.1.1.169] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ol9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ol9 OCA], [http://pdbe.org/4ol9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ol9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ol9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ol9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PANE_MYCTU PANE_MYCTU]] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity).
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[https://www.uniprot.org/uniprot/PANE_MYCTU PANE_MYCTU] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 2-dehydropantoate 2-reductase]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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[[Category: Ketopantoate reductase]]
 
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[[Category: National institute of allergy and infectious disease]]
 
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[[Category: Niaid]]
 
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[[Category: Oxidoreductase]]
 
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[[Category: Ssgcid]]
 

Revision as of 07:31, 25 January 2023

Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate

PDB ID 4ol9

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