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4ow8

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==Crystal structure of kinase domain of PknA from Mtb==
==Crystal structure of kinase domain of PknA from Mtb==
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<StructureSection load='4ow8' size='340' side='right' caption='[[4ow8]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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<StructureSection load='4ow8' size='340' side='right'caption='[[4ow8]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ow8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OW8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ow8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OW8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0018,MTCY10H4.15c,RV0015c,pknA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ow8 OCA], [https://pdbe.org/4ow8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ow8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ow8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ow8 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ow8 OCA], [http://pdbe.org/4ow8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ow8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ow8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ow8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PKNA_MYCTU PKNA_MYCTU]] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:16817899</ref> <ref>PMID:19121323</ref> <ref>PMID:20066037</ref> <ref>PMID:21190553</ref> <ref>PMID:21423706</ref>
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[https://www.uniprot.org/uniprot/PKNA_MYCTU PKNA_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:16817899</ref> <ref>PMID:19121323</ref> <ref>PMID:20066037</ref> <ref>PMID:21190553</ref> <ref>PMID:21423706</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ow8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ow8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Chakraborti, P K]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Karthikeyan, S]]
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[[Category: Chakraborti PK]]
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[[Category: Ravala, S K]]
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[[Category: Karthikeyan S]]
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[[Category: Singh, S]]
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[[Category: Ravala SK]]
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[[Category: Yadav, G S]]
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[[Category: Singh S]]
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[[Category: Drug target]]
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[[Category: Yadav GS]]
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[[Category: Kinase]]
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[[Category: Mtb]]
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[[Category: Pkna]]
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[[Category: Transferase]]
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Revision as of 07:48, 25 January 2023

Crystal structure of kinase domain of PknA from Mtb

PDB ID 4ow8

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