Disintegrin

From Proteopedia

Current revision

spinqualitylabelsall models Disintegrin, 1z1x Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Disintegrins are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. [1] Over 100 disintegrins have been studied. Relevance Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis[2].

3D Structures of Disintegrin

Updated on 30-January-2023

2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR
1j2l – trimestatin - Trimeresurus flavovidrius
2pjf, 1q7i, 1q7j, 1n4y – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR
2pjg, 2pji, 2ljv - Cr rhodostoxin (mutant) 1-68 – NMR
3uci, 4m4c, 4r5r, 4r5u, 4rqg - Cr rhodostoxin (mutant) 408-475
2m75, 2m7f, 2m7h - Cr rhodostoxin (mutant) 408-475 – NMR
1z1x, 1tej – Ec disintegrin – Echis carinatus
1rmr – Ec schistatin
6lsq – Ec echistatin
1ro3, 2ech – Ec echistatin - NMR
1l3x – salmosin – Gloydius brevicaudus – NMR
1mpz – obtustatin – Macrovipera obtusa - NMR
3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead
3dsl – bothropasin - Jararaca
2dw0, 2dw1, 2dw2 – catrocollastatin – rattlesnake
2mop, 2mp5 – bitistatin – African puff adder - NMR

References

1. ↑ McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec;4(4):327-55. PMID:15578957
2. ↑ McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Front Biosci. 2008 May 1;13:6617-37. PMID:18508683