1ihb
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(New page: 200px<br /> <applet load="1ihb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ihb, resolution 1.95Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 15:23, 12 November 2007
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CRYSTAL STRUCTURE OF P18-INK4C(INK6)
Overview
p18INK4c is a member of a family of INK4 proteins that function to arrest, the G1 to S cell cycle transition by inhibiting the activity of the, cyclin-dependent kinases 4 and 6. The X-ray crystal structure of the human, p18INK4c protein to a resolution of 1.95 A reveals an elongated molecule, comprised of five contiguous 32- or 33-residue ankyrin-like repeat units., Each ankyrin-like repeat contains a beta-strand helix-turn-helix extended, strand beta-strand motif that associates with neighboring motifs through, beta-sheet, and helical bundle interactions. Conserved ankyrin-like repeat, residues function to facilitate the ankyrin repeat fold and the tertiary, interactions between neighboring repeat units. A large percentage of, residues that are conserved among INK4 proteins and that map to positions, of tumor-derived p16INK4 mutations play important roles in protein, stability. A subset of these residues suggest an INK4 binding surface for, the cyclin-dependent kinases 4 and 6. This surface is centered around a, region that shows structural features uncharacteristic of ankyrin-like, repeat units.
About this Structure
1IHB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations., Venkataramani R, Swaminathan K, Marmorstein R, Nat Struct Biol. 1998 Jan;5(1):74-81. PMID:9437433
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