3hwr

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<StructureSection load='3hwr' size='340' side='right'caption='[[3hwr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='3hwr' size='340' side='right'caption='[[3hwr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hwr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupnj Cupnj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HWR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hwr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_pinatubonensis_JMP134 Cupriavidus pinatubonensis JMP134]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HWR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Reut_B4967, YP_299159.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264198 CUPNJ])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-dehydropantoate_2-reductase 2-dehydropantoate 2-reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.169 1.1.1.169] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hwr OCA], [https://pdbe.org/3hwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hwr RCSB], [https://www.ebi.ac.uk/pdbsum/3hwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hwr ProSAT], [https://www.topsan.org/Proteins/JCSG/3hwr TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hwr OCA], [https://pdbe.org/3hwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hwr RCSB], [https://www.ebi.ac.uk/pdbsum/3hwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hwr ProSAT], [https://www.topsan.org/Proteins/JCSG/3hwr TOPSAN]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q46RB9_CUPPJ Q46RB9_CUPPJ] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.[RuleBase:RU362068]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 2-dehydropantoate 2-reductase]]
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[[Category: Cupriavidus pinatubonensis JMP134]]
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[[Category: Cupnj]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Structural genomic]]
 
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[[Category: Jcsg]]
 
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[[Category: Nadp]]
 
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[[Category: Oxidoreductase]]
 
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[[Category: Pane/apba family ketopantoate reductase]]
 
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[[Category: Pantothenate biosynthesis]]
 
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[[Category: PSI, Protein structure initiative]]
 
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[[Category: Yp_299159 1]]
 

Revision as of 11:41, 1 February 2023

Crystal structure of PanE/ApbA family ketopantoate reductase (YP_299159.1) from Ralstonia eutropha JMP134 at 2.15 A resolution

PDB ID 3hwr

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