1js2

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[[Image:1js2.gif|left|200px]]
[[Image:1js2.gif|left|200px]]
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{{Structure
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|PDB= 1js2 |SIZE=350|CAPTION= <scene name='initialview01'>1js2</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1js2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1js2| PDB=1js2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js2 OCA], [http://www.ebi.ac.uk/pdbsum/1js2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1js2 RCSB]</span>
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}}
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'''Crystal structure of C77S HiPIP: a serine ligated [4Fe-4S} cluster'''
'''Crystal structure of C77S HiPIP: a serine ligated [4Fe-4S} cluster'''
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[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
[[Category: Xiong, Y.]]
[[Category: Xiong, Y.]]
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[[Category: serine ligated [4fe-4s] cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:48:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:14 2008''
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Revision as of 18:48, 2 May 2008

Image:1js2.gif

Template:STRUCTURE 1js2

Crystal structure of C77S HiPIP: a serine ligated [4Fe-4S} cluster


Overview

The crystal structure of Chromatium vinosum C77S HiPIP has been determined and is compared with that of wild type. This is the first reported crystal structure of a Ser ligated [4Fe-4S] cluster and reveals a 0.11 A shortening of the Fe-O bond (relative to Fe-S), but only minor structural alterations of the overall tertiary structure. Coordination changes are corroborated by resonance Raman spectroscopy. Comparison of the crystal and solution structures for HiPIPs identifies Phe48 as the main controller of solvent access to the Fe-S cluster; however, there is no significant change in cluster solvation of the C77S mutant relative to WT HiPIP. Ser ligation ultimately results in decreased cluster stability due to increased sensitivity to proton mediated degradation.

About this Structure

1JS2 is a Single protein structure of sequence from Allochromatium vinosum. Full crystallographic information is available from OCA.

Reference

Crystal structure and stability studies of C77S HiPIP: a serine ligated [4Fe-4S] cluster., Mansy SS, Xiong Y, Hemann C, Hille R, Sundaralingam M, Cowan JA, Biochemistry. 2002 Jan 29;41(4):1195-201. PMID:11802718 Page seeded by OCA on Fri May 2 21:48:23 2008

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