1js3

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[[Image:1js3.gif|left|200px]]
[[Image:1js3.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1js3 |SIZE=350|CAPTION= <scene name='initialview01'>1js3</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1js3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=142:CARBIDOPA'>142</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase Aromatic-L-amino-acid decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.28 4.1.1.28] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1js3| PDB=1js3 | SCENE= }}
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|RELATEDENTRY=[[1js6|1JS6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js3 OCA], [http://www.ebi.ac.uk/pdbsum/1js3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1js3 RCSB]</span>
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}}
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'''Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa'''
'''Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa'''
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[[Category: Jansonius, J N.]]
[[Category: Jansonius, J N.]]
[[Category: Malashkevich, V N.]]
[[Category: Malashkevich, V N.]]
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[[Category: carbidopa]]
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[[Category: Carbidopa]]
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[[Category: dopa decarboxylase]]
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[[Category: Dopa decarboxylase]]
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[[Category: parkinson's disease]]
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[[Category: Parkinson's disease]]
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[[Category: vitamin b6]]
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[[Category: Vitamin b6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:48:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:11 2008''
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Revision as of 18:49, 2 May 2008

Image:1js3.gif


PDB ID 1js3

Drag the structure with the mouse to rotate
1js3, resolution 2.25Å ()
Ligands: , ,
Activity: Aromatic-L-amino-acid decarboxylase, with EC number 4.1.1.28
Related: 1js6
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa


Overview

DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA. The inhibitor is bound to the enzyme by forming a hydrazone linkage with the cofactor, and its catechol ring is deeply buried in the active site cleft. The structures provide the molecular basis for the development of new inhibitors of DDC with better pharmacological characteristics.

About this Structure

1JS3 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase., Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN, Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:11685243 Page seeded by OCA on Fri May 2 21:48:57 2008

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