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4p5b

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<StructureSection load='4p5b' size='340' side='right'caption='[[4p5b]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
<StructureSection load='4p5b' size='340' side='right'caption='[[4p5b]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4p5b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1602 As 4.1602]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P5B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4p5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_asoensis Streptomyces asoensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P5B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p5a|4p5a]], [[4p5c|4p5c]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p5b OCA], [https://pdbe.org/4p5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p5b RCSB], [https://www.ebi.ac.uk/pdbsum/4p5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p5b ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">polB, thyX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=249586 AS 4.1602])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase_(FAD) Thymidylate synthase (FAD)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.148 2.1.1.148] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p5b OCA], [http://pdbe.org/4p5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p5b RCSB], [http://www.ebi.ac.uk/pdbsum/4p5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p5b ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C1IC19_STRCI C1IC19_STRCI]] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.[HAMAP-Rule:MF_01408]
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[https://www.uniprot.org/uniprot/C1IC19_9ACTN C1IC19_9ACTN] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.[HAMAP-Rule:MF_01408]
==See Also==
==See Also==
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*[[Thymidylate synthase|Thymidylate synthase]]
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: As 4 1602]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, W]]
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[[Category: Streptomyces asoensis]]
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[[Category: Deng, Z]]
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[[Category: Chen W]]
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[[Category: Li, J]]
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[[Category: Deng Z]]
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[[Category: Li, Y]]
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[[Category: Li J]]
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[[Category: Xia, Z]]
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[[Category: Li Y]]
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[[Category: Zhou, J]]
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[[Category: Xia Z]]
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[[Category: Tetramer]]
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[[Category: Zhou J]]
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[[Category: Thyx homolog]]
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[[Category: Transferase]]
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[[Category: Ump/dump methylase]]
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Revision as of 12:42, 1 February 2023

Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br dUMP

PDB ID 4p5b

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