1jst

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[[Image:1jst.gif|left|200px]]
[[Image:1jst.gif|left|200px]]
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{{Structure
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|PDB= 1jst |SIZE=350|CAPTION= <scene name='initialview01'>1jst</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1jst", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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{{STRUCTURE_1jst| PDB=1jst | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jst OCA], [http://www.ebi.ac.uk/pdbsum/1jst PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jst RCSB]</span>
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'''PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A'''
'''PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A'''
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[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Russo, A A.]]
[[Category: Russo, A A.]]
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[[Category: cdk]]
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[[Category: Cdk]]
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[[Category: complex (protein kinase/cyclin)]]
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[[Category: Cyclin]]
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[[Category: cyclin]]
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[[Category: Phosphorylation]]
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[[Category: phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:27 2008''
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Revision as of 18:51, 2 May 2008

Image:1jst.gif

Template:STRUCTURE 1jst

PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A


Overview

Cyclin-dependent kinase (CDK)-cyclin complexes require phosphorylation on the CDK subunit for full activation of their Ser/Thr protein kinase activity. The crystal structure of the phosphorylated CDK2-CyclinA-ATP gamma S complex has been determined at 2.6 A resolution. The phosphate group, which is on the regulatory T-loop of CDK2, is mostly buried, its charge being neutralized by three Arg side chains. The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA. Comparison with the unphosphorylated CDK2-CyclinA complex shows that the T-loop moves by as much as 7 A, and this affects the putative substrate binding site as well as resulting in additional CDK2-CyclinA contacts. The phosphate group thus acts as a major organizing centre in the CDK2-CyclinA complex.

About this Structure

1JST is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of cyclin-dependent kinase activation by phosphorylation., Russo AA, Jeffrey PD, Pavletich NP, Nat Struct Biol. 1996 Aug;3(8):696-700. PMID:8756328 Page seeded by OCA on Fri May 2 21:51:38 2008

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