1jty
From Proteopedia
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'''Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium''' | '''Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium''' | ||
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[[Category: Schumacher, M A.]] | [[Category: Schumacher, M A.]] | ||
[[Category: Skurray, R A.]] | [[Category: Skurray, R A.]] | ||
| - | [[Category: | + | [[Category: Cationic lipophilic drug]] |
| - | [[Category: | + | [[Category: Multidrug binding]] |
| - | [[Category: | + | [[Category: Multidrug recognition mechanism]] |
| - | [[Category: | + | [[Category: Qaca]] |
| - | [[Category: | + | [[Category: Qacr]] |
| - | [[Category: | + | [[Category: Repressor]] |
| - | [[Category: | + | [[Category: Transcription]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:55:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:55, 2 May 2008
Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium
Overview
The Staphylococcus aureus multidrug binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by structurally diverse cationic lipophilic drugs. Here, we report the crystal structures of six QacR-drug complexes. Compared to the DNA bound structure, drug binding elicits a coil-to-helix transition that causes induction and creates an expansive multidrug-binding pocket, containing four glutamates and multiple aromatic and polar residues. These structures indicate the presence of separate but linked drug-binding sites within a single protein. This multisite drug-binding mechanism is consonant with studies on multidrug resistance transporters.
About this Structure
1JTY is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:11739955 Page seeded by OCA on Fri May 2 21:55:10 2008
