7ux4
From Proteopedia
(Difference between revisions)
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<StructureSection load='7ux4' size='340' side='right'caption='[[7ux4]], [[Resolution|resolution]] 2.23Å' scene=''> | <StructureSection load='7ux4' size='340' side='right'caption='[[7ux4]], [[Resolution|resolution]] 2.23Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7ux4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoanaerobacter_pseudethanolicus Thermoanaerobacter pseudethanolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UX4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ux4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoanaerobacter_pseudethanolicus Thermoanaerobacter pseudethanolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7jns 7jns]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UX4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NWO:(1S,3S)-3-methylcyclohexan-1-ol'>NWO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NWO:(1S,3S)-3-methylcyclohexan-1-ol'>NWO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ux4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ux4 OCA], [https://pdbe.org/7ux4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ux4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ux4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ux4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ux4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ux4 OCA], [https://pdbe.org/7ux4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ux4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ux4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ux4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ADH_THEBR ADH_THEBR] Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde. | |
==See Also== | ==See Also== | ||
Revision as of 06:38, 8 February 2023
Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase from Thermoanaerobacter pseudoethanolicus reveal the dynamics of ligand exchange and the proton relay network.
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