7qya
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Proteasome-ZFAND5 Complex Z-B state== | |
| - | + | <StructureSection load='7qya' size='340' side='right'caption='[[7qya]], [[Resolution|resolution]] 4.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qya]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QYA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qya OCA], [https://pdbe.org/7qya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qya RCSB], [https://www.ebi.ac.uk/pdbsum/7qya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qya ProSAT]</span></td></tr> |
| - | [[Category: Lu | + | </table> |
| - | [[Category: Zhu | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PSDE_HUMAN PSDE_HUMAN] Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.<ref>PMID:22909820</ref> <ref>PMID:9374539</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lu Y]] | ||
| + | [[Category: Zhu Y]] | ||
Revision as of 06:40, 8 February 2023
Proteasome-ZFAND5 Complex Z-B state
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