7s1d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of E.coli DsbA in complex with compound MIPS-0001877 (compound 39)== | |
| - | + | <StructureSection load='7s1d' size='340' side='right'caption='[[7s1d]], [[Resolution|resolution]] 1.59Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7s1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S1D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=648:1-[3-(thiophen-3-yl)benzyl]piperidin-2-one'>648</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s1d OCA], [https://pdbe.org/7s1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s1d RCSB], [https://www.ebi.ac.uk/pdbsum/7s1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s1d ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Heras | + | [https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Caria S]] | ||
| + | [[Category: Heras B]] | ||
| + | [[Category: Martin JL]] | ||
| + | [[Category: Scanlon MJ]] | ||
Revision as of 06:41, 8 February 2023
Crystal structure of E.coli DsbA in complex with compound MIPS-0001877 (compound 39)
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