8h59

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'''Unreleased structure'''
 
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The entry 8h59 is ON HOLD until Paper Publication
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==A fungal MAP kinase in complex with an inhibitor==
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<StructureSection load='8h59' size='340' side='right'caption='[[8h59]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8h59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_oryzae_70-15 Pyricularia oryzae 70-15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H59 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KR9:~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide'>KR9</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h59 OCA], [https://pdbe.org/8h59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h59 RCSB], [https://www.ebi.ac.uk/pdbsum/8h59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h59 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPS1_MAGO7 MPS1_MAGO7] Mitogen-activated protein kinase; part of the MCK1-MKK2-MPS1 MAP kinase (MAPK) signal transduction cascade that is essential for cell wall integrity and plant infection, but not for plant defense responses (PubMed:9770551, PubMed:18344407, PubMed:22321443, PubMed:28799700, PubMed:28424497). Beside its role in pathogenesis, the MPS1 cascade is active in conidiation and cellular stress responses (PubMed:9770551). Targets downstream of the MPS1-MAPK pathway include transcription factors MIG1 and SWI6, as well as GSK1 and MPG1 (PubMed:18344407, PubMed:22321443, PubMed:28424497).<ref>PMID:18344407</ref> <ref>PMID:22321443</ref> <ref>PMID:28424497</ref> <ref>PMID:28799700</ref> <ref>PMID:9770551</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pyricularia oryzae 70-15]]
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[[Category: Kong Z]]
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[[Category: Liu J]]
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[[Category: Wang D]]
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[[Category: Zhang X]]

Revision as of 06:49, 8 February 2023

A fungal MAP kinase in complex with an inhibitor

PDB ID 8h59

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