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4pn7

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Revision as of 07:19, 8 February 2023

Crystal Structure of the TFIIH p34 N-terminal Domain

Structural highlights

4pn7 is a 1 chain structure with sequence from Chaetomium thermophilum var. thermophilum DSM 1495. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G0RXV8_CHATD

Publication Abstract from PubMed

RNA polymerase II dependent transcription and nucleotide excision repair are mediated by a multifaceted interplay of subunits within the general transcription factor II H (TFIIH). A better understanding of the molecular structure of TFIIH is the key to unravel the mechanism of action of this versatile protein complex within these vital cellular processes. The importance of this complex becomes further evident in the context of severe diseases like xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy, that arise from single point mutations in TFIIH subunits. Here we describe the structure of the p34 subunit of the TFIIH complex from the eukaryotic thermophilic fungus Chaetomium thermophilum. The structure revealed that p34 contains a von Willebrand Factor A (vWA) like domain, a fold which is generally known to be involved in protein-protein interactions. Within TFIIH p34 strongly interacts with p44, a positive regulator of the helicase XPD. Putative protein-protein interfaces are analyzed and possible binding sites for the p34-p44 interaction suggested.

The Structure of the TFIIH p34 Subunit Reveals a Von Willebrand Factor A Like Fold.,Schmitt DR, Kuper J, Elias A, Kisker C PLoS One. 2014 Jul 11;9(7):e102389. doi: 10.1371/journal.pone.0102389., eCollection 2014. PMID:25013903^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Schmitt DR, Kuper J, Elias A, Kisker C. The Structure of the TFIIH p34 Subunit Reveals a Von Willebrand Factor A Like Fold. PLoS One. 2014 Jul 11;9(7):e102389. doi: 10.1371/journal.pone.0102389., eCollection 2014. PMID:25013903 doi:http://dx.doi.org/10.1371/journal.pone.0102389

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4pn7"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of the TFIIH p34 N-terminal Domain==
-<StructureSection load='4pn7' size='340' side='right' caption='[[4pn7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<StructureSection load='4pn7' size='340' side='right'caption='[[4pn7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4pn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PN7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4pn7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PN7 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0004460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pn7 OCA], [https://pdbe.org/4pn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pn7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pn7 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pn7 OCA], [http://pdbe.org/4pn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pn7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pn7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pn7 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/G0RXV8_CHATD G0RXV8_CHATD]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Chatd]]
+[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
-[[Category: Elias, A]]
+[[Category: Large Structures]]
-[[Category: Kisker, C]]
+[[Category: Elias A]]
-[[Category: Kuper, J]]
+[[Category: Kisker C]]
-[[Category: Schmitt, D R]]
+[[Category: Kuper J]]
-[[Category: Transcription]]
+[[Category: Schmitt DR]]
-[[Category: Vwa domain]]

4pn7

From Proteopedia

Revision as of 07:19, 8 February 2023

Crystal Structure of the TFIIH p34 N-terminal Domain

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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