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4pxu

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==Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers==
==Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers==
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<StructureSection load='4pxu' size='340' side='right' caption='[[4pxu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4pxu' size='340' side='right'caption='[[4pxu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pxu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PXU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pxu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PXU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pxt|4pxt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxu OCA], [https://pdbe.org/4pxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pxu RCSB], [https://www.ebi.ac.uk/pdbsum/4pxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pxu ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG9191, KLP2, Klp61F, Klp61F or DmKlp61F or CG9191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxu OCA], [http://pdbe.org/4pxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pxu RCSB], [http://www.ebi.ac.uk/pdbsum/4pxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pxu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KL61_DROME KL61_DROME]] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
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[https://www.uniprot.org/uniprot/KL61_DROME KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4pxu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4pxu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Al-Bassam, J]]
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[[Category: Large Structures]]
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[[Category: Nithianantham, S]]
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[[Category: Al-Bassam J]]
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[[Category: Scholey, J E]]
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[[Category: Nithianantham S]]
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[[Category: Scholey, J M]]
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[[Category: Scholey JE]]
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[[Category: Anti-parallel four-helix bundle]]
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[[Category: Scholey JM]]
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[[Category: Bipolar assembly domain of kinesin-5]]
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[[Category: Bipolar tetramer]]
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[[Category: Cell cycle]]
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[[Category: Coiled-coil]]
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[[Category: Crosslinking adjacent microtubules into bundles throughout the mitotic spindle]]
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[[Category: Kinesin-5 functions via a sliding filament mechanism]]
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[[Category: Microtubule]]
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Revision as of 07:36, 8 February 2023

Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers

PDB ID 4pxu

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