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4pz6

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<StructureSection load='4pz6' size='340' side='right'caption='[[4pz6]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='4pz6' size='340' side='right'caption='[[4pz6]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pz6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz6 OCA], [https://pdbe.org/4pz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pz6 RCSB], [https://www.ebi.ac.uk/pdbsum/4pz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz6 ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pz7|4pz7]], [[4pz8|4pz8]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ceg1, ceg1/pce1, pce1, SPBC2F12.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_guanylyltransferase mRNA guanylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.50 2.7.7.50] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz6 OCA], [http://pdbe.org/4pz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pz6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MCE1_SCHPO MCE1_SCHPO]] Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate (By similarity). [[http://www.uniprot.org/uniprot/RPB1_SCHPO RPB1_SCHPO]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity).
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[https://www.uniprot.org/uniprot/MCE1_SCHPO MCE1_SCHPO] Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fission yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: MRNA guanylyltransferase]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Doamekpor, S K]]
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[[Category: Doamekpor SK]]
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[[Category: Lima, C D]]
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[[Category: Lima CD]]
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[[Category: Guanylation]]
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[[Category: Nuclear]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Rna capping enzyme]]
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[[Category: Rna polymerase ii]]
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[[Category: Spt5]]
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[[Category: Transferase-transcription complex]]
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Revision as of 07:38, 8 February 2023

PCE1 guanylyltransferase bound to SER2/SER5 phosphorylated RNA pol II CTD

PDB ID 4pz6

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