4pzg
From Proteopedia
(Difference between revisions)
Line 3: | Line 3: | ||
<StructureSection load='4pzg' size='340' side='right'caption='[[4pzg]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4pzg' size='340' side='right'caption='[[4pzg]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4pzg]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4pzg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PZG FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pzg OCA], [https://pdbe.org/4pzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pzg RCSB], [https://www.ebi.ac.uk/pdbsum/4pzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pzg ProSAT]</span></td></tr> | |
- | + | ||
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
- | [ | + | [https://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN] Autosomal recessive malignant osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22499339</ref> <ref>PMID:23123320</ref> <ref>PMID:23280965</ref> |
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN] Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.<ref>PMID:17012226</ref> <ref>PMID:21844891</ref> <ref>PMID:22499339</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Line 24: | Line 22: | ||
==See Also== | ==See Also== | ||
- | *[[Sorting nexin|Sorting nexin]] | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Liu | + | [[Category: Liu J]] |
- | [[Category: Wang | + | [[Category: Wang Q]] |
- | [[Category: Xu | + | [[Category: Xu J]] |
- | [[Category: Xu | + | [[Category: Xu T]] |
- | + | ||
- | + | ||
- | + |
Revision as of 07:38, 8 February 2023
Crystal structure of human sorting nexin 10 (SNX10)
|
Categories: Homo sapiens | Large Structures | Liu J | Wang Q | Xu J | Xu T