End-binding protein
From Proteopedia
(Difference between revisions)
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| - | '''End-binding protein''' or '''telomere-binding protein''' (EB) regulates microtubules dynamics, promotes colony formation and enhances tumor growth. EB is part of the proteins which accumulate at the growing microtubule plus end. During mitosis the EB associates with centrosome and spindle microtubules. EB is involved in the regulation of chromosome stability and microtubule structure. The C terminal domains of EB1 and EB3 are involved in dimer formation. The CH (Calponin Homology) domain is an actin-binding domain<ref>PMID:11470413</ref>. | + | '''End-binding protein''' or '''telomere-binding protein''' or '''microtubule-associated protein RP/EB family member''' (EB) regulates microtubules dynamics, promotes colony formation and enhances tumor growth. EB is part of the proteins which accumulate at the growing microtubule plus end. During mitosis the EB associates with centrosome and spindle microtubules. EB is involved in the regulation of chromosome stability and microtubule structure. The C terminal domains of EB1 and EB3 are involved in dimer formation. The CH (Calponin Homology) domain is an actin-binding domain<ref>PMID:11470413</ref>. |
</StructureSection> | </StructureSection> | ||
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**[[3gjo]] – hEB1 C terminal + dystonin<br /> | **[[3gjo]] – hEB1 C terminal + dystonin<br /> | ||
**[[2qjz]] – hEB1 CH domain 12-133<br /> | **[[2qjz]] – hEB1 CH domain 12-133<br /> | ||
| + | **[[5n74]] – hEB1 + KAR9 <br /> | ||
**[[1v5k]] – mEB1 CH domain (mutant) – mouse - NMR<br /> | **[[1v5k]] – mEB1 CH domain (mutant) – mouse - NMR<br /> | ||
**[[6evi]] – mEB1 C-terminal 191-260 - NMR<br /> | **[[6evi]] – mEB1 C-terminal 191-260 - NMR<br /> | ||
| + | **[[6evj]] – mEB1 C-terminal + modulator - NMR<br /> | ||
| + | **[[7olg]] – mEB1 C-terminal + peptide - NMR<br /> | ||
| + | **[[1k8g]], [[1kix]], [[1otc]], [[1ph1]], [[1ph2]], [[1ph3]], [[1ph4]], [[1ph5]], [[1ph6]], [[1ph7]], [[1ph8]], [[1ph9]], [[1phj]] – EB1 alpha+beta subunits + DNA – ''Sterkiella nova'' <br /> | ||
*End-binding protein 3 | *End-binding protein 3 | ||
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**[[3co1]] – hEB3 CH domain <br /> | **[[3co1]] – hEB3 CH domain <br /> | ||
**[[1wyo]] – hEB3 CH domain - NMR<br /> | **[[1wyo]] – hEB3 CH domain - NMR<br /> | ||
| + | **[[3jak]], [[7sj9]] – hEB3 + tubulin – Cryo EM <br /> | ||
| + | **[[3jal]] – hEB3 + tubulin + GMPCPP – Cryo EM <br /> | ||
*End-binding protein 1+3 | *End-binding protein 1+3 | ||
Revision as of 10:23, 14 February 2023
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3D Structures of end-binding protein
Updated on 14-February-2023
