7r1i
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor== | |
| - | + | <StructureSection load='7r1i' size='340' side='right'caption='[[7r1i]], [[Resolution|resolution]] 2.24Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7r1i]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R1I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HIH:ethyl+1-(2-piperidin-4-ylethyl)-5-pyridin-4-yl-indole-2-carboxylate'>HIH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r1i OCA], [https://pdbe.org/7r1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r1i RCSB], [https://www.ebi.ac.uk/pdbsum/7r1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r1i ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CP125_MYCTU CP125_MYCTU] Catalyzes the C-27 hydroxylation of cholest-4-en-3-one and cholesterol and subsequently oxidizes the alcohol of the former to the cholest-4-en-3-one-27-oic acid via the aldehyde intermediate. Not required to incorporate the cholesterol side-chain carbon atoms into cellular lipids.<ref>PMID:19846551</ref> <ref>PMID:20545858</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Katariya M]] | ||
| + | [[Category: Levy C]] | ||
| + | [[Category: Leys D]] | ||
| + | [[Category: Snee M]] | ||
Revision as of 10:19, 15 February 2023
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
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