7tym

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'''Unreleased structure'''
 
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The entry 7tym is ON HOLD until Paper Publication
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==Cryo-EM Structure of insulin receptor-related receptor (IRR) in active-state captured at pH 9. The 3D refinement was applied with C2 symmetry==
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<StructureSection load='7tym' size='340' side='right'caption='[[7tym]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7tym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TYM FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tym OCA], [https://pdbe.org/7tym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tym RCSB], [https://www.ebi.ac.uk/pdbsum/7tym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tym ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INSRR_HUMAN INSRR_HUMAN] Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.<ref>PMID:21641549</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bai XC]]
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[[Category: Choi E]]
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[[Category: Hall C]]
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[[Category: Li J]]
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[[Category: Wang LW]]

Revision as of 10:21, 15 February 2023

Cryo-EM Structure of insulin receptor-related receptor (IRR) in active-state captured at pH 9. The 3D refinement was applied with C2 symmetry

PDB ID 7tym

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OCA

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