8fhn

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'''Unreleased structure'''
 
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The entry 8fhn is ON HOLD until Paper Publication
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==Cryo-EM structure of human NCC (class 2)==
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<StructureSection load='8fhn' size='340' side='right'caption='[[8fhn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fhn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FHN FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=XZF:Polythiazide'>XZF</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fhn OCA], [https://pdbe.org/8fhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fhn RCSB], [https://www.ebi.ac.uk/pdbsum/8fhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fhn ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/S12A3_HUMAN S12A3_HUMAN] Gitelman syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/S12A3_HUMAN S12A3_HUMAN] Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145). Receptor for the pro-inflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).[UniProtKB:P59158]<ref>PMID:21613606</ref> <ref>PMID:22009145</ref> [https://www.uniprot.org/uniprot/S12A2_DANRE S12A2_DANRE] Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:31367042). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:31367042). Important for maintenance of endolymph volume in the otic vesicle, probably by regulating ion homeostasis (PubMed:19633174). Also plays a role in normal development of the swim bladder (PubMed:19633174).<ref>PMID:19633174</ref> <ref>PMID:31367042</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Danio rerio]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fan M]]
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[[Category: Feng L]]
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[[Category: Zhang J]]

Revision as of 10:29, 15 February 2023

Cryo-EM structure of human NCC (class 2)

PDB ID 8fhn

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