7e1f
From Proteopedia
(Difference between revisions)
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==Native-DBD== | ==Native-DBD== | ||
| - | <StructureSection load='7e1f' size='340' side='right'caption='[[7e1f]]' scene=''> | + | <StructureSection load='7e1f' size='340' side='right'caption='[[7e1f]], [[Resolution|resolution]] 1.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1F FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1f OCA], [https://pdbe.org/7e1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1f RCSB], [https://www.ebi.ac.uk/pdbsum/7e1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1f ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1f OCA], [https://pdbe.org/7e1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1f RCSB], [https://www.ebi.ac.uk/pdbsum/7e1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0L8SKF9_VIBPH A0A0L8SKF9_VIBPH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | <p indent="0mm">Two-component systems typically consist of a paired histidine kinase and response regulator and couple environmental changes to adaptive responses. The response regulator VbrR from <italic>Vibrio parahaemolyticus</italic>, a member of the OmpR/PhoB family, regulates virulence and antibiotic resistance genes. The activation mechanism of VbrR remains unclear. Here, we report the crystal structures of full-length VbrR in complex with DNA in the active conformation and the N-terminal receiver domain (RD) and the C-terminal DNA-binding domain (DBD) in both active and inactive conformations. Structural and biochemical analyses suggest that unphosphorylated VbrR adopts mainly as inactive dimers through the DBD at the autoinhibitory state. The RD undergoes a monomer-to-dimer transition upon phosphorylation, which further induces the transition of DBD from an autoinhibitory dimer to an active dimer and enables its binding with target DNA. Our study suggests a new model for phosphorylation-induced activation of response regulators and sheds light on the pathogenesis of <italic>V</italic>. <italic>parahaemolyticus</italic>. </p>. | ||
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| + | Structural basis of phosphorylation-induced activation of the response regulator VbrR.,Hong S, Guo J, Zhang X, Zhou X, Zhang P, Yu F Acta Biochim Biophys Sin (Shanghai). 2023 Jan 9. doi: 10.3724/abbs.2022200. PMID:36647726<ref>PMID:36647726</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7e1f" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Response regulator 3D structure|Response regulator 3D structure]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio parahaemolyticus]] | ||
[[Category: Hong S]] | [[Category: Hong S]] | ||
[[Category: Zhang P]] | [[Category: Zhang P]] | ||
Revision as of 10:32, 15 February 2023
Native-DBD
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