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1jwt

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[[Image:1jwt.jpg|left|200px]]
[[Image:1jwt.jpg|left|200px]]
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{{Structure
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|PDB= 1jwt |SIZE=350|CAPTION= <scene name='initialview01'>1jwt</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1jwt", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BLI:4-OXO-2-PHENYLMETHANESULFONYL-OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE-6-CARBOXYLIC+ACID+[1-(N-HYDROXYCARBAMIMIDOYL)-PIPERIDIN-4-YLMETHYL]-AMIDE'>BLI</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1jwt| PDB=1jwt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jwt OCA], [http://www.ebi.ac.uk/pdbsum/1jwt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jwt RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR'''
'''CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR'''
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[[Category: St-Denis, Y.]]
[[Category: St-Denis, Y.]]
[[Category: Winocour, P D.]]
[[Category: Winocour, P D.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:01:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:09 2008''
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Revision as of 19:01, 2 May 2008

Image:1jwt.jpg

Template:STRUCTURE 1jwt

CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR


Overview

Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo.

About this Structure

1JWT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues., Levesque S, St-Denis Y, Bachand B, Preville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA, Bioorg Med Chem Lett. 2001 Dec 17;11(24):3161-4. PMID:11720865 Page seeded by OCA on Fri May 2 22:01:19 2008

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