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1jx6

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[[Image:1jx6.gif|left|200px]]
[[Image:1jx6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jx6 |SIZE=350|CAPTION= <scene name='initialview01'>1jx6</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1jx6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi])
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-->
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|DOMAIN=
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{{STRUCTURE_1jx6| PDB=1jx6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2'''
'''CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2'''
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[[Category: Potier, N.]]
[[Category: Potier, N.]]
[[Category: Schauder, S.]]
[[Category: Schauder, S.]]
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[[Category: protein-ligand complex]]
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[[Category: Protein-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:02:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:18 2008''
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Revision as of 19:02, 2 May 2008

Image:1jx6.gif

Template:STRUCTURE 1jx6

CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2


Overview

Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression. Community cooperation probably enhances the effectiveness of processes such as bioluminescence, virulence factor expression, antibiotic production and biofilm development. Unlike other autoinducers, which are specific to a particular species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bacterial species. AI-2 has been proposed to serve as a 'universal' signal for inter-species communication. The chemical identity of AI-2 has, however, proved elusive. Here we present the crystal structure of an AI-2 sensor protein, LuxP, in a complex with autoinducer. The bound ligand is a furanosyl borate diester that bears no resemblance to previously characterized autoinducers. Our findings suggest that addition of naturally occurring borate to an AI-2 precursor generates active AI-2. Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.

About this Structure

1JX6 is a Single protein structure of sequence from Vibrio harveyi. Full crystallographic information is available from OCA.

Reference

Structural identification of a bacterial quorum-sensing signal containing boron., Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM, Nature. 2002 Jan 31;415(6871):545-9. PMID:11823863 Page seeded by OCA on Fri May 2 22:02:01 2008

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