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2lpf

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Revision as of 11:11, 15 February 2023

R state structure of monomeric phospholamban (C36A, C41F, C46A)

Structural highlights

2lpf is a 1 chain structure with sequence from Oryctolagus cuniculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PPLA_RABIT Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.

Publication Abstract from PubMed

Phospholamban is an integral membrane protein that controls the calcium balance in cardiac muscle cells. As the function and regulation of this protein require the active involvement of low populated states in equilibrium with the native state, it is of great interest to acquire structural information about them. In this work we determine the conformations and populations of the ground state and the three main excited states of phospholamban by incorporating nuclear magnetic resonance (NMR) residual dipolar couplings (RDCs) as replica-averaged structural restraints in molecular dynamics simulations. We then provide a description of the manner in which phosphorylation at Ser16 modulates the activity of the protein by increasing the populations of its excited states. These results demonstrate that approach that we describe provides a detailed characterisation of the different states of phospholamban that determine the function and regulation of this membrane protein. We anticipate that the availability of conformational ensembles will provide opportunities for the development of therapeutic strategies to control the activity of phospholamban by modulating the relative populations of its conformational substates.

Structures of the Excited States of Phospholamban and Shifts in their Populations upon Phosphorylation.,De Simone A, Gustavsson MB, Montalvao RW, Shi L, Veglia G, Vendruscolo M Biochemistry. 2013 Aug 22. PMID:23968132^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ De Simone A, Gustavsson MB, Montalvao RW, Shi L, Veglia G, Vendruscolo M. Structures of the Excited States of Phospholamban and Shifts in their Populations upon Phosphorylation. Biochemistry. 2013 Aug 22. PMID:23968132 doi:10.1021/bi400517b

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lpf"

@@ Line 1: / Line 1: @@
 ==R state structure of monomeric phospholamban (C36A, C41F, C46A)==
-<StructureSection load='2lpf' size='340' side='right'caption='[[2lpf]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='2lpf' size='340' side='right'caption='[[2lpf]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2lpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2lpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPF FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n7l|1n7l]], [[2kb7|2kb7]], [[2kyv|2kyv]]</div></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpf OCA], [https://pdbe.org/2lpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpf RCSB], [https://www.ebi.ac.uk/pdbsum/2lpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpf ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpf OCA], [https://pdbe.org/2lpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpf RCSB], [https://www.ebi.ac.uk/pdbsum/2lpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpf ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/PPLA_RABIT PPLA_RABIT]] Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
+[https://www.uniprot.org/uniprot/PPLA_RABIT PPLA_RABIT] Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 24: @@
 __TOC__
 </StructureSection>
-[[Category: European rabbit]]
 [[Category: Large Structures]]
-[[Category: Gustavsson, M]]
+[[Category: Oryctolagus cuniculus]]
-[[Category: Montalvao, R W]]
+[[Category: De Simone A]]
-[[Category: Shi, L]]
+[[Category: Gustavsson M]]
-[[Category: Simone, A De]]
+[[Category: Montalvao RW]]
-[[Category: Veglia, G]]
+[[Category: Shi L]]
-[[Category: Vendruscolo, M]]
+[[Category: Veglia G]]
-[[Category: Dilated cardiomyopathy]]
+[[Category: Vendruscolo M]]
-[[Category: Excited state]]
-[[Category: Membrane protein]]
-[[Category: Phospholamban]]

2lpf

From Proteopedia

Revision as of 11:11, 15 February 2023

R state structure of monomeric phospholamban (C36A, C41F, C46A)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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