2lr8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A==
==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A==
-
<StructureSection load='2lr8' size='340' side='right'caption='[[2lr8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2lr8' size='340' side='right'caption='[[2lr8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR8 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR8 FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP8AP2, FLASH, KIAA1315, RIP25 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [https://pdbe.org/2lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [https://pdbe.org/2lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN]] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref>
+
[https://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Acton, T B]]
+
[[Category: Acton TB]]
-
[[Category: Eletsky, A]]
+
[[Category: Eletsky A]]
-
[[Category: Everett, J K]]
+
[[Category: Everett JK]]
-
[[Category: Janjua, H]]
+
[[Category: Janjua H]]
-
[[Category: Kohan, E]]
+
[[Category: Kohan E]]
-
[[Category: Lee, D]]
+
[[Category: Lee D]]
-
[[Category: Montelione, G T]]
+
[[Category: Montelione GT]]
-
[[Category: Structural genomic]]
+
[[Category: Pulavarti S]]
-
[[Category: Pulavarti, S]]
+
[[Category: Sathyamoorthy B]]
-
[[Category: Sathyamoorthy, B]]
+
[[Category: Sukumaran DK]]
-
[[Category: Sukumaran, D K]]
+
[[Category: Szyperski T]]
-
[[Category: Szyperski, T]]
+
[[Category: Xiao R]]
-
[[Category: Xiao, R]]
+
-
[[Category: Apoptosis]]
+
-
[[Category: Nesg]]
+
-
[[Category: Psi-biology]]
+

Revision as of 11:13, 15 February 2023

Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A

PDB ID 2lr8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lr8"
Personal tools