4qca

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<StructureSection load='4qca' size='340' side='right'caption='[[4qca]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4qca' size='340' side='right'caption='[[4qca]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qca]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vacca Vacca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QCA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qca]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Ankara Vaccinia virus Ankara]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QCA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dof|4dof]], [[4dog|4dog]], [[4lzb|4lzb]], [[4irb|4irb]], [[4qc9|4qc9]], [[4qcb|4qcb]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qca OCA], [https://pdbe.org/4qca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qca RCSB], [https://www.ebi.ac.uk/pdbsum/4qca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qca ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACAM3000_MVA_101, D4, MVA101R, UNG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126794 VACCA])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qca OCA], [http://pdbe.org/4qca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qca RCSB], [http://www.ebi.ac.uk/pdbsum/4qca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qca ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UNG_VACCA UNG_VACCA]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.
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[https://www.uniprot.org/uniprot/UNG_VACCW UNG_VACCW] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[DNA glycosylase|DNA glycosylase]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Uracil-DNA glycosylase]]
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[[Category: Vaccinia virus Ankara]]
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[[Category: Vacca]]
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[[Category: Banerjee S]]
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[[Category: Banerjee, S]]
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[[Category: Chattopadhyay D]]
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[[Category: Chattopadhyay, D]]
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[[Category: Nash T]]
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[[Category: Nash, T]]
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[[Category: Nuth M]]
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[[Category: Nuth, M]]
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[[Category: Ricciardi R]]
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[[Category: Ricciardi, R]]
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[[Category: Sartmatova D]]
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[[Category: Sartmatova, D]]
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[[Category: Schormann N]]
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[[Category: Schormann, N]]
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[[Category: A20]]
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[[Category: Component of processivity factor]]
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[[Category: Dna]]
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[[Category: Dna repair enzyme]]
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[[Category: Hydrolase]]
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[[Category: Poxvirus]]
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Revision as of 11:23, 15 February 2023

Crystal structure of Vaccinia virus uracil-DNA glycosylase mutant R167AD4

PDB ID 4qca

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