1jxs
From Proteopedia
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'''Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor''' | '''Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor''' | ||
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[[Category: Li, C.]] | [[Category: Li, C.]] | ||
[[Category: Liu, P P.]] | [[Category: Liu, P P.]] | ||
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| - | [[Category: | + | [[Category: Winged helix]] |
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Revision as of 19:03, 2 May 2008
Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor
Overview
Interleukin enhancer binding factor (ILF) binds to the interleukin-2 (IL-2) promoter and regulates IL-2 gene expression. In this study, the 3D structure of the DNA-binding domain of ILF was determined by multidimensional NMR spectroscopy. NMR structure analysis revealed that the DNA-binding domain of ILF is a new member of the winged helix/forkhead family, and that its wing 2 contains an extra alpha-helix. This is the first study to report the presence of a C-terminal alpha-helix in place of a typical wing 2 in a member of this family. This structural difference may be responsible for the different DNA-binding specificity of ILF compared to other winged helix/forkhead proteins. Our deletion studies of the fragments of ILF also suggest that the C-terminal region plays a regulatory role in DNA binding.
About this Structure
1JXS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)., Liu PP, Chen YC, Li C, Hsieh YH, Chen SW, Chen SH, Jeng WY, Chuang WJ, Proteins. 2002 Dec 1;49(4):543-53. PMID:12402362 Page seeded by OCA on Fri May 2 22:03:18 2008
