8b0f
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of C5b8-CD59== | |
| - | + | <StructureSection load='8b0f' size='340' side='right'caption='[[8b0f]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8b0f]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0f OCA], [https://pdbe.org/8b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0f RCSB], [https://www.ebi.ac.uk/pdbsum/8b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0f ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Bubeck | + | [https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:[https://omim.org/entry/612446 612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bubeck D]] | ||
| + | [[Category: Couves EC]] | ||
| + | [[Category: Gardner S]] | ||
Revision as of 12:40, 22 February 2023
CryoEM structure of C5b8-CD59
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