8ez1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8ez1 is ON HOLD until Paper Publication
+
==Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid==
-
 
+
<StructureSection load='8ez1' size='340' side='right'caption='[[8ez1]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
-
Authors: Butrin, A., Shen, S., Silverman, R., Liu, D.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8ez1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EZ1 FirstGlance]. <br>
-
Description: Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X8B:(3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic+acid'>X8B</scene>, <scene name='pdbligand=X8H:(1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic+acid'>X8H</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ez1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ez1 OCA], [https://pdbe.org/8ez1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ez1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ez1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ez1 ProSAT]</span></td></tr>
-
[[Category: Liu, D]]
+
</table>
-
[[Category: Shen, S]]
+
== Disease ==
-
[[Category: Butrin, A]]
+
[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[https://omim.org/entry/258870 258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>
-
[[Category: Silverman, R]]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Butrin A]]
 +
[[Category: Liu D]]
 +
[[Category: Shen S]]
 +
[[Category: Silverman R]]

Revision as of 12:44, 22 February 2023

Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid

PDB ID 8ez1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools