1jzn

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[[Image:1jzn.gif|left|200px]]
[[Image:1jzn.gif|left|200px]]
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{{Structure
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|PDB= 1jzn |SIZE=350|CAPTION= <scene name='initialview01'>1jzn</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1jzn", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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{{STRUCTURE_1jzn| PDB=1jzn | SCENE= }}
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|RELATEDENTRY=[[1muq|1MUQ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzn OCA], [http://www.ebi.ac.uk/pdbsum/1jzn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jzn RCSB]</span>
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'''crystal structure of a galactose-specific C-type lectin'''
'''crystal structure of a galactose-specific C-type lectin'''
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[[Category: Walker, J R.]]
[[Category: Walker, J R.]]
[[Category: Young, N M.]]
[[Category: Young, N M.]]
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[[Category: c-type lectin]]
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[[Category: C-type lectin]]
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[[Category: protein-disaccharide complex]]
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[[Category: Protein-disaccharide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:07:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:16 2008''
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Revision as of 19:07, 2 May 2008

Image:1jzn.gif

Template:STRUCTURE 1jzn

crystal structure of a galactose-specific C-type lectin


Overview

Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.

About this Structure

1JZN is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:15049685 Page seeded by OCA on Fri May 2 22:07:02 2008

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