1k05

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[[Image:1k05.jpg|left|200px]]
[[Image:1k05.jpg|left|200px]]
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{{Structure
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|PDB= 1k05 |SIZE=350|CAPTION= <scene name='initialview01'>1k05</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1k05", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|GENE= FAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1k05| PDB=1k05 | SCENE= }}
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|RELATEDENTRY=[[1k04|1K04]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k05 OCA], [http://www.ebi.ac.uk/pdbsum/1k05 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k05 RCSB]</span>
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'''Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase'''
'''Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase'''
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[[Category: Hoellerer, M K.]]
[[Category: Hoellerer, M K.]]
[[Category: Noble, M E.M.]]
[[Category: Noble, M E.M.]]
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[[Category: up-down-up-down four helical bundle]]
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[[Category: Up-down-up-down four helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:08:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:27 2008''
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Revision as of 19:08, 2 May 2008

Image:1k05.jpg

Template:STRUCTURE 1k05

Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase


Overview

The localization of focal adhesion kinase (FAK) to sites of integrin clustering initiates downstream signaling. The C-terminal focal adhesion targeting (FAT) domain causes this localization by interacting with talin and paxillin. FAT also mediates signaling through Grb2 via phosphorylated Y925. We report two crystal structures of the FAT domain. Large rearrangements of the structure are indicated to allow phosphorylation of Y925 and subsequent interaction with Grb2. Sequence homology and structural compatibility suggest a FAT-like fold for the C-terminal domains of CAS, Efs/Sin, and HEF1. A structure-based alignment including these proteins and the vinculin tail domain reveals a conserved region that could play a role in focal adhesion targeting. Previously postulated "paxillin binding subdomains" may contribute to structural integrity rather than directly to paxillin binding.

About this Structure

1K05 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis of localization and signaling by the focal adhesion targeting domain., Arold ST, Hoellerer MK, Noble ME, Structure. 2002 Mar;10(3):319-27. PMID:12005431 Page seeded by OCA on Fri May 2 22:08:09 2008

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