2m85
From Proteopedia
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==PHD Domain from Human SHPRH== | ==PHD Domain from Human SHPRH== | ||
| - | <StructureSection load='2m85' size='340' side='right'caption='[[2m85 | + | <StructureSection load='2m85' size='340' side='right'caption='[[2m85]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M85 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fui|2fui]], [[1xwh|1xwh]], [[1wep|1wep]], [[2jmi|2jmi]], [[2vpd|2vpd]], [[2rsd|2rsd]], [[1x4i|1x4i]], [[2k16|2k16]], [[2k1j|2k1j]], [[2kkg|2kkg]]</div></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHPRH, KIAA2023 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m85 OCA], [https://pdbe.org/2m85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m85 RCSB], [https://www.ebi.ac.uk/pdbsum/2m85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m85 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m85 OCA], [https://pdbe.org/2m85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m85 RCSB], [https://www.ebi.ac.uk/pdbsum/2m85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m85 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Almeida | + | [[Category: Almeida FCL]] |
| - | [[Category: Bezsonova | + | [[Category: Bezsonova I]] |
| - | [[Category: Korzhnev | + | [[Category: Korzhnev DM]] |
| - | [[Category: Machado | + | [[Category: Machado LESF]] |
| - | [[Category: Pozhidaeva | + | [[Category: Pozhidaeva A]] |
| - | [[Category: Pustovalova | + | [[Category: Pustovalova Y]] |
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Revision as of 13:33, 22 February 2023
PHD Domain from Human SHPRH
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