4dn8

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<StructureSection load='4dn8' size='340' side='right'caption='[[4dn8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4dn8' size='340' side='right'caption='[[4dn8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DN8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DN8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFTPD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dn8 OCA], [https://pdbe.org/4dn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dn8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dn8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dn8 OCA], [https://pdbe.org/4dn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dn8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dn8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SFTPD_PIG SFTPD_PIG]] Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
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[https://www.uniprot.org/uniprot/SFTPD_PIG SFTPD_PIG] Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pig]]
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[[Category: Sus scrofa]]
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[[Category: Cafarella, T M]]
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[[Category: Cafarella TM]]
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[[Category: Crouch, E C]]
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[[Category: Crouch EC]]
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[[Category: Eijk, M van]]
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[[Category: Haagsman HP]]
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[[Category: Haagsman, H P]]
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[[Category: Hartshorn KL]]
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[[Category: Hartshorn, K L]]
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[[Category: Head JF]]
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[[Category: Head, J F]]
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[[Category: Luo D]]
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[[Category: Luo, D]]
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[[Category: Rynkiewicz MJ]]
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[[Category: Rynkiewicz, M J]]
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[[Category: Schulten K]]
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[[Category: Schulten, K]]
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[[Category: Seaton BA]]
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[[Category: Seaton, B A]]
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[[Category: White MR]]
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[[Category: White, M R]]
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[[Category: Zou X]]
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[[Category: Zou, X]]
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[[Category: Van Eijk M]]
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[[Category: Carbohydrate/sugar binding]]
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[[Category: Collectin]]
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[[Category: Lectin]]
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[[Category: Lung surfactant]]
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[[Category: Sugar binding protein]]
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Revision as of 13:37, 22 February 2023

Structure of porcine surfactant protein D neck and carbohydrate recognition domain complexed with mannose

PDB ID 4dn8

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