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1k09

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[[Image:1k09.jpg|left|200px]]
[[Image:1k09.jpg|left|200px]]
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{{Structure
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|PDB= 1k09 |SIZE=350|CAPTION= <scene name='initialview01'>1k09</scene>
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The line below this paragraph, containing "STRUCTURE_1k09", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=CLG:2-AMINO-6-[2-(2-AMINOOXY-ACETYLAMINO)-ACETYLAMINO]-HEXANOIC+ACID'>CLG</scene>, <scene name='pdbligand=CLH:2-AMINO-6-[2-(2-OXO-ACETYLAMINO)-ACETYLAMINO]-HEXANOIC+ACID'>CLH</scene>, <scene name='pdbligand=MPT:BETA-MERCAPTOPROPIONIC+ACID'>MPT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>
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{{STRUCTURE_1k09| PDB=1k09 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k09 OCA], [http://www.ebi.ac.uk/pdbsum/1k09 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k09 RCSB]</span>
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'''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein'''
'''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein'''
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==About this Structure==
==About this Structure==
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1K09 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].
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1K09 is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].
==Reference==
==Reference==
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[[Category: Carulla, N.]]
[[Category: Carulla, N.]]
[[Category: Woodward, C.]]
[[Category: Woodward, C.]]
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[[Category: four-stranded antiparallel beta-sheet]]
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[[Category: Four-stranded antiparallel beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:08:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:31 2008''
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Revision as of 19:08, 2 May 2008

Image:1k09.jpg

Template:STRUCTURE 1k09

Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein


Overview

BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.

About this Structure

1K09 is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452 Page seeded by OCA on Fri May 2 22:08:25 2008

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