4qt6
From Proteopedia
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==Crystal structure of the SPRY domain of human HERC1== | ==Crystal structure of the SPRY domain of human HERC1== | ||
| - | <StructureSection load='4qt6' size='340' side='right' caption='[[4qt6]], [[Resolution|resolution]] 1.64Å' scene=''> | + | <StructureSection load='4qt6' size='340' side='right'caption='[[4qt6]], [[Resolution|resolution]] 1.64Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QT6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt6 OCA], [https://pdbe.org/4qt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qt6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qt6 ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Dong | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Dong A]] |
| - | [[Category: Guan | + | [[Category: Edwards AM]] |
| - | [[Category: Hu | + | [[Category: Guan X]] |
| - | [[Category: Li | + | [[Category: Hu J]] |
| - | + | [[Category: Li Y]] | |
| - | [[Category: Tong | + | [[Category: Tong Y]] |
| - | [[Category: Wernimont | + | [[Category: Wernimont A]] |
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Revision as of 13:51, 22 February 2023
Crystal structure of the SPRY domain of human HERC1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Dong A | Edwards AM | Guan X | Hu J | Li Y | Tong Y | Wernimont A
