|
|
| Line 1: |
Line 1: |
| | | | |
| | ==Crystal Structure of FLHE== | | ==Crystal Structure of FLHE== |
| - | <StructureSection load='4qxl' size='340' side='right' caption='[[4qxl]], [[Resolution|resolution]] 1.51Å' scene=''> | + | <StructureSection load='4qxl' size='340' side='right'caption='[[4qxl]], [[Resolution|resolution]] 1.51Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4qxl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QXL FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4qxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QXL FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FLHE, SEEA0014_18915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28901 "Bacillus cholerae-suis" Smith 1894])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxl OCA], [https://pdbe.org/4qxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qxl RCSB], [https://www.ebi.ac.uk/pdbsum/4qxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxl ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxl OCA], [http://pdbe.org/4qxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qxl RCSB], [http://www.ebi.ac.uk/pdbsum/4qxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxl ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| Line 16: |
Line 15: |
| | </div> | | </div> |
| | <div class="pdbe-citations 4qxl" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 4qxl" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Flagellar protein 3D structures|Flagellar protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus cholerae-suis smith 1894]] | + | [[Category: Large Structures]] |
| - | [[Category: Harshey, R M]] | + | [[Category: Salmonella enterica]] |
| - | [[Category: Keatinge-Clay, A T]] | + | [[Category: Harshey RM]] |
| - | [[Category: Lee, J]] | + | [[Category: Keatinge-Clay AT]] |
| - | [[Category: Monzingo, A F]]
| + | [[Category: Lee J]] |
| - | [[Category: Beta-sandwich]]
| + | [[Category: Monzingo AF]] |
| - | [[Category: Flagellar type iii secretion system]] | + | |
| - | [[Category: Motor protein]] | + | |
| - | [[Category: Periplasmic]]
| + | |
| - | [[Category: Secretion pore plug]]
| + | |
| Structural highlights
Publication Abstract from PubMed
The bacterial flagellum is assembled by a multicomponent transport apparatus categorized as a Type III secretion (T3S) system. The secretion of proteins that assemble into the flagellum is driven by the proton motive force. The periplasmic protein FlhE is a member of the flhBAE operon in the majority of bacteria where FlhE is found. FlhA and FlhB are established components of the flagellar T3S system. The absence of FlhE results in a proton leak through the flagellar system, inappropriate secretion patterns, and cell death, indicating that FlhE regulates an important aspect of proper flagellar biosynthesis. We isolated FlhE from the periplasm of Salmonella and solved its structure to 1.5A resolution. Possible roles of FlhE, including that of a chaperone, are discussed.
Structure of Salmonella FlhE, conserved member of a flagellar Type III secretion operon.,Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM J Mol Biol. 2014 Dec 26. pii: S0022-2836(14)00647-0. doi:, 10.1016/j.jmb.2014.11.022. PMID:25545591[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM. Structure of Salmonella FlhE, conserved member of a flagellar Type III secretion operon. J Mol Biol. 2014 Dec 26. pii: S0022-2836(14)00647-0. doi:, 10.1016/j.jmb.2014.11.022. PMID:25545591 doi:http://dx.doi.org/10.1016/j.jmb.2014.11.022
|
