This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4qxs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4qxs' size='340' side='right'caption='[[4qxs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4qxs' size='340' side='right'caption='[[4qxs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4qxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QXS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4qxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QXS FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=WC1:(2-{2-[(2S)-3-METHYLBUTAN-2-YL]-5-PHENYL-1H-INDOL-3-YL}ETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>WC1</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=WC1:(2-{2-[(2S)-3-METHYLBUTAN-2-YL]-5-PHENYL-1H-INDOL-3-YL}ETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>WC1</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxs OCA], [https://pdbe.org/4qxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qxs RCSB], [https://www.ebi.ac.uk/pdbsum/4qxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxs ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxs OCA], [http://pdbe.org/4qxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qxs RCSB], [http://www.ebi.ac.uk/pdbsum/4qxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxs ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 20:
==See Also==
==See Also==
-
*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
+
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Berghuis, A M]]
+
[[Category: Berghuis AM]]
-
[[Category: Park, J]]
+
[[Category: Park J]]
-
[[Category: Tsantrizos, Y S]]
+
[[Category: Tsantrizos YS]]
-
[[Category: Weiling, C]]
+
[[Category: Weiling C]]
-
[[Category: Zielinski, M]]
+
[[Category: Zielinski M]]
-
[[Category: Transferase-transferase inhibitor complex]]
+

Revision as of 13:58, 22 February 2023

Crystal structure of human FPPS in complex with WC01088

PDB ID 4qxs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4qxs"
Personal tools