4r09

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4r09' size='340' side='right'caption='[[4r09]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='4r09' size='340' side='right'caption='[[4r09]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4r09]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R09 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4r09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R09 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=06S:O-[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-3,6-DIHYDRO-9H-PURIN-9-YL)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-HYDROXY-2-[(THIOPHOSPHONOOXY)METHYL]TETRAHYDROFURAN-3-YL}OXY)(SULFANYL)PHOSPHORYL]OXY}METHYL)-4-HYDROXYTETRAHYDROFURAN-3-YL]+DIHYDROGEN+(S)-PHOSPHOROTHIOATE'>06S</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPT:1-[(2R,3AR,4R,6R,6AR)-2-HYDROXY-6-(HYDROXYMETHYL)-2-SULFIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]PYRIMIDINE-2,4(1H,3H)-DIONE'>UPT</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06S:O-[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-3,6-DIHYDRO-9H-PURIN-9-YL)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-HYDROXY-2-[(THIOPHOSPHONOOXY)METHYL]TETRAHYDROFURAN-3-YL}OXY)(SULFANYL)PHOSPHORYL]OXY}METHYL)-4-HYDROXYTETRAHYDROFURAN-3-YL]+DIHYDROGEN+(S)-PHOSPHOROTHIOATE'>06S</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPT:1-[(2R,3AR,4R,6R,6AR)-2-HYDROXY-6-(HYDROXYMETHYL)-2-SULFIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]PYRIMIDINE-2,4(1H,3H)-DIONE'>UPT</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r07|4r07]], [[4r08|4r08]], [[4r0a|4r0a]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r09 OCA], [https://pdbe.org/4r09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r09 RCSB], [https://www.ebi.ac.uk/pdbsum/4r09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r09 ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r09 OCA], [http://pdbe.org/4r09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r09 RCSB], [http://www.ebi.ac.uk/pdbsum/4r09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r09 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
+
[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 20:
==See Also==
==See Also==
-
*[[Toll-like Receptors|Toll-like Receptors]]
+
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ohto, U]]
+
[[Category: Ohto U]]
-
[[Category: Shimizu, T]]
+
[[Category: Shimizu T]]
-
[[Category: Tanji, H]]
+
[[Category: Tanji H]]
-
[[Category: Antitumor drug binding]]
+
-
[[Category: Antiviral binding]]
+
-
[[Category: Glycosylation]]
+
-
[[Category: Immune system]]
+
-
[[Category: Innate immunity]]
+
-
[[Category: Leucine rich repeat]]
+
-
[[Category: Rna]]
+
-
[[Category: Rna binding]]
+
-
[[Category: Rna receptor]]
+
-
[[Category: Rna recognition]]
+
-
[[Category: Ssrna]]
+

Revision as of 14:02, 22 February 2023

Crystal structure of human TLR8 in complex with ORN06S

PDB ID 4r09

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4r09"
Personal tools