1k0w

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[[Image:1k0w.jpg|left|200px]]
[[Image:1k0w.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1k0w |SIZE=350|CAPTION= <scene name='initialview01'>1k0w</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1k0w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-ribulose-5-phosphate_4-epimerase L-ribulose-5-phosphate 4-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.4 5.1.3.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ARAD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1k0w| PDB=1k0w | SCENE= }}
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|RELATEDENTRY=[[1jdi|1JDI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0w OCA], [http://www.ebi.ac.uk/pdbsum/1k0w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k0w RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE'''
'''CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE'''
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[[Category: Samuel, J.]]
[[Category: Samuel, J.]]
[[Category: Strynadka, N C.J.]]
[[Category: Strynadka, N C.J.]]
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[[Category: aldolase]]
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[[Category: Aldolase]]
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[[Category: epimerase]]
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[[Category: Epimerase]]
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[[Category: ribulose]]
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[[Category: Ribulose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:09:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:46 2008''
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Revision as of 19:09, 2 May 2008

Image:1k0w.jpg

Template:STRUCTURE 1k0w

CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE


Overview

The structure of L-ribulose-5-phosphate 4-epimerase from E. coli has been solved to 2.4 A resolution using X-ray diffraction data. The structure is homo-tetrameric and displays C(4) symmetry. Each subunit has a single domain comprised of a central beta-sheet flanked on either side by layers of alpha-helices. The active site is identified by the position of the catalytic zinc residue and is located at the interface between two adjacent subunits. A remarkable feature of the structure is that it shows a very close resemblance to that of L-fuculose-1-phosphate aldolase. This is consistent with the notion that both enzymes belong to a superfamily of epimerases/aldolases that catalyze carbon-carbon bond cleavage reactions via a metal-stabilized enolate intermediate. Detailed inspection of the epimerase structure, however, indicates that despite the close overall structural similarity to class II aldolases, the enzyme has evolved distinct active site features that promote its particular chemistry.

About this Structure

1K0W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization., Luo Y, Samuel J, Mosimann SC, Lee JE, Tanner ME, Strynadka NC, Biochemistry. 2001 Dec 11;40(49):14763-71. PMID:11732895 Page seeded by OCA on Fri May 2 22:09:58 2008

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