8ftu

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'''Unreleased structure'''
 
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The entry 8ftu is ON HOLD until Paper Publication
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==Crystal structure of the SNARE Use1 bound to Dsl1 complex subunits Sec39 and Dsl1, Revised Use1 structure==
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<StructureSection load='8ftu' size='340' side='right'caption='[[8ftu]], [[Resolution|resolution]] 5.73&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ftu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6wc4 6wc4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FTU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ftu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ftu OCA], [https://pdbe.org/8ftu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ftu RCSB], [https://www.ebi.ac.uk/pdbsum/8ftu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ftu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6CWC7_KLULA Q6CWC7_KLULA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Most membrane fusion reactions in eukaryotic cells are mediated by membrane tethering complexes (MTCs) and SNARE proteins. MTCs are much larger than SNAREs and are thought to mediate the initial attachment of two membranes. Complementary SNAREs then form membrane-bridging complexes whose assembly draws the membranes together for fusion. Here, we present a cryo-EM structure of the simplest known MTC, the 255-kDa Dsl1 complex, bound to the two SNAREs that anchor it to the endoplasmic reticulum. N-terminal domains of the SNAREs form an integral part of the structure, stabilizing a Dsl1 complex configuration with remarkable and unexpected similarities to the 850-kDa exocyst MTC. The structure of the SNARE-anchored Dsl1 complex and its comparison with exocyst reveal what are likely to be common principles underlying MTC function. Our structure also implies that tethers and SNAREs can work together as a single integrated machine.
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Authors: Travis, S.M., Jeffrey, P.D., Hughson, F.M.
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Structure of a Membrane Tethering Complex Incorporating Multiple SNAREs.,DAmico KA, Stanton AE, Shirkey JD, Travis SM, Jeffrey PD, Hughson FM bioRxiv. 2023 Jan 30:2023.01.30.526244. doi: 10.1101/2023.01.30.526244. Preprint. PMID:36778436<ref>PMID:36778436</ref>
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Description: Crystal structure of the SNARE Use1 bound to Dsl1 complex subunits Sec39 and Dsl1, Revised Use1 structure
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Travis, S.M]]
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<div class="pdbe-citations 8ftu" style="background-color:#fffaf0;"></div>
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[[Category: Hughson, F.M]]
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== References ==
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[[Category: Jeffrey, P.D]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
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[[Category: Large Structures]]
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[[Category: Hughson FM]]
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[[Category: Jeffrey PD]]
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[[Category: Travis SM]]

Revision as of 05:57, 2 March 2023

Crystal structure of the SNARE Use1 bound to Dsl1 complex subunits Sec39 and Dsl1, Revised Use1 structure

PDB ID 8ftu

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