8fjp

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'''Unreleased structure'''
 
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The entry 8fjp is ON HOLD
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==Cryo-EM structure of native mosquito salivary gland surface protein 1 (SGS1)==
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<StructureSection load='8fjp' size='340' side='right'caption='[[8fjp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fjp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FJP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fjp OCA], [https://pdbe.org/8fjp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fjp RCSB], [https://www.ebi.ac.uk/pdbsum/8fjp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fjp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q16U82_AEDAE Q16U82_AEDAE]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Female mosquitoes inject saliva into vertebrate hosts during blood feeding. This process transmits mosquito-borne human pathogens that collectively cause ~1,000,000 deaths/year. Among the most abundant and conserved proteins secreted by female salivary glands is a high-molecular weight protein called salivary gland surface protein 1 (SGS1) that facilitates pathogen transmission, but its mechanism remains elusive. Here, we determine the native structure of SGS1 by the cryoID approach, showing that the 3364 amino-acid protein has a Tc toxin-like Rhs/YD shell, four receptor domains, and a set of C-terminal daisy-chained helices. These helices are partially shielded inside the Rhs/YD shell and poised to transform into predicted transmembrane helices. This transformation, and the numerous receptor domains on the surface of SGS1, are likely key in facilitating sporozoite/arbovirus invasion into the salivary glands and manipulating the host's immune response.
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Authors:
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Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission.,Liu S, Xia X, Calvo E, Zhou ZH Nat Commun. 2023 Feb 17;14(1):899. doi: 10.1038/s41467-023-36577-y. PMID:36797290<ref>PMID:36797290</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 8fjp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aedes aegypti]]
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[[Category: Large Structures]]
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[[Category: Calvo E]]
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[[Category: Liu S]]
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[[Category: Xia X]]
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[[Category: Zhou ZH]]

Revision as of 06:05, 2 March 2023

Cryo-EM structure of native mosquito salivary gland surface protein 1 (SGS1)

PDB ID 8fjp

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