7e3h
From Proteopedia
(Difference between revisions)
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==Crystal structure of human acetylcholinesterase in complex with donepezil== | ==Crystal structure of human acetylcholinesterase in complex with donepezil== | ||
| - | <StructureSection load='7e3h' size='340' side='right'caption='[[7e3h]]' scene=''> | + | <StructureSection load='7e3h' size='340' side='right'caption='[[7e3h]], [[Resolution|resolution]] 2.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E3H FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e3h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E3H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e3h OCA], [https://pdbe.org/7e3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e3h RCSB], [https://www.ebi.ac.uk/pdbsum/7e3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e3h ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E20:1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE'>E20</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e3h OCA], [https://pdbe.org/7e3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e3h RCSB], [https://www.ebi.ac.uk/pdbsum/7e3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e3h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
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| + | ==See Also== | ||
| + | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Dileep KV]] | [[Category: Dileep KV]] | ||
Revision as of 06:09, 2 March 2023
Crystal structure of human acetylcholinesterase in complex with donepezil
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