2ma1

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==Solution structure of HRDC1 domain of RecQ helicase from Deinococcus radiodurans==
==Solution structure of HRDC1 domain of RecQ helicase from Deinococcus radiodurans==
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<StructureSection load='2ma1' size='340' side='right'caption='[[2ma1]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='2ma1' size='340' side='right'caption='[[2ma1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ma1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deira Deira]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ma1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DrRecQ, DR_1289 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 DEIRA])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma1 OCA], [https://pdbe.org/2ma1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma1 OCA], [https://pdbe.org/2ma1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma1 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9RUU2_DEIRA Q9RUU2_DEIRA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RecQ helicase from Deinococcus radiodurans (DrRecQ) distinguishes from other helicases in that it utilizes its three 'helicase and RNaseD C-terminal' domains (HRDC1, HRDC2 and HRDC3) to regulate its activity. These HRDC domains have different influence on the biochemical functions of DrRecQ. Currently, only the structure of HRDC3 was reported. Here, we determined the NMR structure of the N-terminal-most HRDC1, revealing a potential DNA binding domain. Fluorescence anisotropy assay indicates that HRDC1 has binding affinity weaker than 70 muM to all DNA substrates without any specificity. Biochemical assays suggested that HRDC1 cooperates with other domains to enhance full-length DrRecQ interactions with DNA.
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NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans.,Liu S, Zhang W, Gao Z, Ming Q, Hou H, Lan W, Wu H, Cao C, Dong Y FEBS Lett. 2013 Aug 19;587(16):2635-42. doi: 10.1016/j.febslet.2013.06.048. Epub , 2013 Jul 4. PMID:23831579<ref>PMID:23831579</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ma1" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deira]]
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[[Category: Deinococcus radiodurans R1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cao, C]]
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[[Category: Cao C]]
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[[Category: Dong, Y]]
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[[Category: Dong Y]]
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[[Category: Gao, Z]]
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[[Category: Gao Z]]
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[[Category: Hou, H]]
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[[Category: Hou H]]
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[[Category: Lan, W]]
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[[Category: Lan W]]
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[[Category: Liu, S]]
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[[Category: Liu S]]
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[[Category: Ming, Q]]
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[[Category: Ming Q]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Zhang, W]]
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[[Category: Zhang W]]
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[[Category: Dna binding protein]]
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[[Category: Recq hrdc domain 1]]
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Revision as of 06:28, 2 March 2023

Solution structure of HRDC1 domain of RecQ helicase from Deinococcus radiodurans

PDB ID 2ma1

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