2mbz

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==Structural Basis of a Thiopeptide Antibiotic Multidrug Resistance System from Streptomyces lividans:Promothiocin A in Complex with TipAS==
==Structural Basis of a Thiopeptide Antibiotic Multidrug Resistance System from Streptomyces lividans:Promothiocin A in Complex with TipAS==
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<StructureSection load='2mbz' size='340' side='right'caption='[[2mbz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2mbz' size='340' side='right'caption='[[2mbz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mbz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mbz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBZ FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=MOZ:(2Z)-2-AMINO-3-HYDROXYBUT-2-ENOIC+ACID'>MOZ</scene>, <scene name='pdbligand=NAK:AMINO-ACRYLATE'>NAK</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=MOZ:(2Z)-2-AMINO-3-HYDROXYBUT-2-ENOIC+ACID'>MOZ</scene>, <scene name='pdbligand=NAK:AMINO-ACRYLATE'>NAK</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ny9|1ny9]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tipA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbz OCA], [https://pdbe.org/2mbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbz RCSB], [https://www.ebi.ac.uk/pdbsum/2mbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbz OCA], [https://pdbe.org/2mbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbz RCSB], [https://www.ebi.ac.uk/pdbsum/2mbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TIPA_STRLI TIPA_STRLI]] Transcriptional activator. Is activated when bound to the antibiotic thiostrepton.
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[https://www.uniprot.org/uniprot/TIPA_STRLI TIPA_STRLI] Transcriptional activator. Is activated when bound to the antibiotic thiostrepton.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allan, M G]]
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[[Category: Streptomyces lividans]]
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[[Category: Grzesiek, S]]
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[[Category: Synthetic construct]]
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[[Category: Habazettl, J]]
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[[Category: Allan MG]]
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[[Category: Jensen, P]]
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[[Category: Grzesiek S]]
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[[Category: Sass, H]]
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[[Category: Habazettl J]]
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[[Category: Multidrug recognition]]
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[[Category: Jensen P]]
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[[Category: Protein/antibiotic]]
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[[Category: Sass H]]
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[[Category: Protein/thiopeptide]]
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[[Category: Tipas/promothiocin some]]
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[[Category: Transcription activator-antibiotic complex]]
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[[Category: Transcriptional activator]]
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Revision as of 06:30, 2 March 2023

Structural Basis of a Thiopeptide Antibiotic Multidrug Resistance System from Streptomyces lividans:Promothiocin A in Complex with TipAS

PDB ID 2mbz

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