4i54
From Proteopedia
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<StructureSection load='4i54' size='340' side='right'caption='[[4i54]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4i54' size='340' side='right'caption='[[4i54]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4i54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4i54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I54 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1C1:AMINO({[(1R,2R)-1-({[(4-CHLORO-3-FLUOROPHENYL)AMINO](OXO)ACETYL}AMINO)-2,3-DIHYDRO-1H-INDEN-2-YL]METHYL}AMINO)METHANIMINIUM'>1C1</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1C1:AMINO({[(1R,2R)-1-({[(4-CHLORO-3-FLUOROPHENYL)AMINO](OXO)ACETYL}AMINO)-2,3-DIHYDRO-1H-INDEN-2-YL]METHYL}AMINO)METHANIMINIUM'>1C1</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i54 OCA], [https://pdbe.org/4i54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i54 RCSB], [https://www.ebi.ac.uk/pdbsum/4i54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i54 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i54 OCA], [https://pdbe.org/4i54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i54 RCSB], [https://www.ebi.ac.uk/pdbsum/4i54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i54 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hendrickson | + | [[Category: Hendrickson WA]] |
| - | [[Category: Le-Khac | + | [[Category: Le-Khac M]] |
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Revision as of 06:37, 2 March 2023
Crystal structure of clade A/E 93TH057 HIV-1 gp120 H375S core in complex with DMJ-II-121
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