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| | <StructureSection load='4r3q' size='340' side='right'caption='[[4r3q]], [[Resolution|resolution]] 1.90Å' scene=''> | | <StructureSection load='4r3q' size='340' side='right'caption='[[4r3q]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3Q FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3Q FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Syce3, Tseg2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [https://pdbe.org/4r3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [https://www.ebi.ac.uk/pdbsum/4r3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3q ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [http://pdbe.org/4r3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [http://www.ebi.ac.uk/pdbsum/4r3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3q ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/SYCE3_MOUSE SYCE3_MOUSE]] Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.<ref>PMID:20407872</ref> <ref>PMID:21637789</ref> | + | [https://www.uniprot.org/uniprot/SYCE3_MOUSE SYCE3_MOUSE] Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.<ref>PMID:20407872</ref> <ref>PMID:21637789</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Feng, J]] | + | [[Category: Feng J]] |
| - | [[Category: Lu, J]] | + | [[Category: Lu J]] |
| - | [[Category: Shen, Y]] | + | [[Category: Shen Y]] |
| - | [[Category: Yang, X]] | + | [[Category: Yang X]] |
| - | [[Category: Zhou, W]] | + | [[Category: Zhou W]] |
| - | [[Category: Cell cycle]]
| + | |
| - | [[Category: Coiled-coil]]
| + | |
| - | [[Category: Synaptonemal complex]]
| + | |
| Structural highlights
Function
SYCE3_MOUSE Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.[1] [2]
Publication Abstract from PubMed
The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements.
Structural insight into the central element assembly of the synaptonemal complex.,Lu J, Gu Y, Feng J, Zhou W, Yang X, Shen Y Sci Rep. 2014 Nov 14;4:7059. doi: 10.1038/srep07059. PMID:25394919[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hu T, Wang Z, Zeng F, Chen X, Gu Z, Zheng L, Tong Q. Expression pattern of testis-specific expressed gene 2 in cryptorchidism model and its role in apoptosis of spermatogenic cells. J Huazhong Univ Sci Technolog Med Sci. 2010 Apr;30(2):193-7. doi:, 10.1007/s11596-010-0212-3. Epub 2010 Apr 21. PMID:20407872 doi:http://dx.doi.org/10.1007/s11596-010-0212-3
- ↑ Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Hoog C, Cooke HJ, Alsheimer M, Benavente R. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. PLoS Genet. 2011 May;7(5):e1002088. doi: 10.1371/journal.pgen.1002088. Epub 2011 , May 26. PMID:21637789 doi:http://dx.doi.org/10.1371/journal.pgen.1002088
- ↑ Lu J, Gu Y, Feng J, Zhou W, Yang X, Shen Y. Structural insight into the central element assembly of the synaptonemal complex. Sci Rep. 2014 Nov 14;4:7059. doi: 10.1038/srep07059. PMID:25394919 doi:http://dx.doi.org/10.1038/srep07059
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